Gene Regulation Info

Towards quantitative descriptions of gene regulation

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Welcome to Gene Regulation Info

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This site is devoted to the quantitative description of gene regulation. It will store reviews of relevant internet resources (e.g. DNA-protein interaction databases, nucleosome positioning servers, and more items to come later), aggregated gene-regulation news (the right panel), the list of conferences and schools, as well as an overview of my own projects. You can contact me with any comments, suggestions and links or just post at the new forum.

-- Vladimir Teif

 

Research Interests

A mixture of gene regulatory modelsKnowing the information about all molecular players and rules of their interaction, Nature "calculates" the transcription level for each gene. Is this biological game computable on a man-made computer? I take this as a working hypothesis. My current projects are aimed to develop a general methodology for the calculation of site- and context-specific multiprotein assembly on the DNA lattice and connect the mechanistic molecular logic of gene-regulation functions with the formal mathematics of systems biology in order to predict gene expression in chromatin. See the Projects section for details.

 

Upcoming events

Here is a list of upcoming events -- conferences, summer schools, workshops and other meetings relevant to the quantitative gene regulation. I am regularly updating this list. Events are listed chronologically starting from 2009. Come again later and check for updates. Also feel free to submit new entries.

 

Science online: some considerations and links

"Science 2.0" is a concept introduced several years ago to describe the next wave of science. We don't know what it is (or what it should be), but it definitely will be more advanced and probably more internet-based. Science will be changed by the technological advances and sociological changes, but how exactly is not clear. It seems that tomorrow's science will involve five basic features: (1) comments at the web sites of online journals, (2) community exchange hubs, (3) personal blogs, (4) brainstorming hubs, and (5) online networking hubs. Below are some my considerations and the lists of existing online-science initiatives.

Read more...
 

Nucleosome positioning data and tools

A collection of sites with nucleosome positioning data is started here. I am interested both in theoretical tools online and experimental databases. This list is being constantly updated, feel free to contact me to submit new links.

 

Protein-DNA binding parameters

I have started collecting online resources on protein-DNA binding parameters here. I am interested both in the thermodynamic parameters (Kd, deltaG, km, ks, etc) and the position weight matrices (PWMs). This list is being constantly updated, feel free to contact me to submit new links.